Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1
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چکیده
منابع مشابه
Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1.
Susceptibility to complex disease appears to be partly mediated by heritable differences in gene expression. Where cis-acting effects on a gene's expression influence disease susceptibility, other genes containing polymorphism with a trans-acting effect on expression of that gene may also be expected to modulate risk. Use of the expression of an identified disease gene as an endophenotype for q...
متن کاملDTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release
Schizophrenia is one of the most debilitating neuropsychiatric disorders, affecting 0.5-1.0% of the population worldwide. Its pathology, attributed to defects in synaptic transmission, remains elusive. The dystrobrevin-binding protein 1 (DTNBP1) gene, which encodes a coiled-coil protein, dysbindin, is a major susceptibility gene for schizophrenia. Our previous results have demonstrated that the...
متن کاملPolymorphic Cis- and Trans-Regulation of Human Gene Expression
Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in genetic studies where the entire genome can be scanned for regulators without prior knowledge of the regulatory mechanisms, thus enabling the identification of unknown regulatory relationships. Here, we carried out such genetic analyses with...
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Multiple studies have linked podocyte gene variants to diverse sporadic nephropathies, including HIV-1-associated nephropathy (HIVAN). We previously used linkage analysis to identify a major HIVAN susceptibility locus in mouse, HIVAN1. We performed expression quantitative trait locus (eQTL) analysis of podocyte genes in HIV-1 transgenic mice to gain further insight into genetic susceptibility t...
متن کاملRelationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia.
OBJECTIVE The purpose of this study was to determine whether a haplotype in the dystrobrevin binding protein 1 (DTNBP1) gene previously associated with schizophrenia not only increases the susceptibility to psychotic illness but also to a more or less clinically specific form of psychotic illness. METHOD In the Irish Study of High-Density Schizophrenia Families, subjects with psychotic illnes...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2008
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddn006